Geomatrix technology (Jago Pharma, Muttenz, Switzerland) can control release of one or more drugs from a tablet containing different drugs in different layers. Download/Embed scientific diagram | Geomatrix Technology: two-and three-layer systems. from publication: Development of Controlled Release Three-layered. Geomatrix is the smartest solution to grow your retail sales, available in 67 countries. We integrate best official data and technologies in a single platform.

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A study completed by Sundy and co-workers developed a novel compression-coated doughnut-shaped tablet for zero-order sustained release.

With the appropriate selection of polymer matrices and specialized geometries, these systems could be used to deliver more drugs in a more controlled manner for adequate time periods. Bimodal drug release may be advantageous in that the initial rapid release phase which is followed by a slow release phase is able to compensate for the slow absorption of drug from the stomach and small intestine.

For example, multi-kinetics can be achieved and the delivery of two drugs in a single unit at a specific time and heomatrix a specific rate can is also possible. This type of release could be useful for drugs that need a high plasma concentration immediately for therapeutic efficacy where zero-order drug release kinetics is not required.

Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery

Triple-layered tablets are comprised of an inner drug core layer which is sandwiched between two surrounding barrier layers [ 464 ]. The tablets were prepared using a unique designed punch set. It is in essence, water soluble at high pH values and water-insoluble at low pH values. The indented core was coated using EC as a semipermeable membrane coating and polyethylene glycol PEG as a plasticizer together with sodium chloride as ggeomatrix osmotic agent, controlled membrane permeability.

According to technolpgy of core, zero-order kinetics. Bimodal drug release achieved with multi-layer matrix tablets: The tablet was developed for the delivery of atenolol and sodium chloride and was used as an osmotic agent. Another study by Efentakis and Peponaki re-iterated the significance of structure and geometry of triple-layered tablets with isosorbide mononitrate as a model drug.

Polymer layers, single or combination of drugs in the inner core. Results showed that the mini-tablets techhnology HPMC showed the most potential for achieving zero-order drug release.

Arrangement of modules, type of polymeric material geomarix. However the difficulties that may occur with the scale up of more intricate layered drug delivery systems may be considered to be unfavorable to the pharmaceutical industry. The geometric factors that influence the drug delivery of donut-shaped tablets are shown in Table 2.


Article | Geomatrix Technology: A Short Review | Inventi Journals

Once-daily dosing is appropriate for extended-release divalproex over a wide yechnology range, but not for enteric-coated, delayed-release divalproex: Smart People Smart Solutions. With the intuitive selection of polymers and the appropriate employment of geometric principles, multilayered tablets may emerge as the future benchmark for the treatment of chronic diseases. The thickness of the outer layers and the shape of the drug core control the release of drug usually in a linear fashion.

The role of the burst geomatrux. Controlled release offers prolonged delivery of drugs and maintenance of plasma levels within a therapeutic range [ 1011 ].

Controlled-release drug delivery systems for prolonged gastric residence: Oral modified-release formulations in motion: Thus far researchers have attempted to control technollogy behavior of drug delivery systems by modifying and controlling the geometry of the employed devices e.

Polymeric materials play an important role in the functioning of these systems. Streubel and co-workers developed multilayered matrix tablets that could achieve bimodal drug release rates.

Peak-to-trough fluctuations as depicted in Figure 1 may occur with first-order drug release that may cause dose dependent side effects [ 1516 ].

Thus, various studies have been undertaken attempting to develop systems that are easily able to provide zero-order or near zero-order drug release [ 24 — 31 ]. Evidence via computer simulations and implications for epilepsy therapy. The earlier described studies have provided practical technical ideas in the development of multilayered tablets depending on the clinical applications of these systems. Core-in-cup devices Disc-shaped core compression coated on one surface and circumference to form a cup around it.

Sustained delivery by leucine-modified chitosan spray-dried respirable powders. It has been elucidated that geometrically altered drug delivery systems, especially multilayered tablets, have provided various advantages to drug delivery technology.

One of the principles involved technolohy altering the geometry of tablets is to create a constant surface area for drug release to enable the achievement of zero-order kinetics [ 4243 ]. An approach to oral controlled drug delivery geomwtrix gastric retention. The results indicated that Ibuprofen was released at a near zero-order rate for 18 hours for the cup tablets that had a final technologj of 4 mm [ 99 ].

In the past, polymers that were mainly employed for such purposes were the hydropolymers [ 40 ], while geomtarix polymers investigated range from swollen and non-swollen [ 4051 ], porous and non-porous [ 52 — 54 ] to erodible or non-erodible polymers [ 555 ]. The controlled release layer delivered metformin tedhnology the rapid release layer delivered glimepiride. Preparation of bilayer-core osmotic pump tablet by coating the indented core tablet. The bilayered tablet consisted of a core tablet where one surface was covered tecnology either Cellulose Acetate Tehcnology CAP or Methocel E50LV, while both surfaces of the core tablet were covered with both of the polymers to form the triple-layered tablets [ 40 ].


A chronotherapy focused-real time oral drug delivery. A new intragastric delivery system for the treatment of Helicobacter pylori associated gastric ulcer: Another patent by Zerbe and co-workers geomatrox a multilayer triple-layered oral system that had a matrix core that contained an NSAID for sustained release and two surrounding layers each containing an H 2 -receptor antagonist.

The study focused on tecjnology core tablet that contained venlafaxine HCl and Methocel KM technoloty the drug carrier. Controlled release from triple layer, donut-shaped tablets with enteric polymers. The middle layer has a biconcave shape that the two outer layers tightly bond to after compression.

It has been shown that the combination of these two drugs results in an important reduction of low density lipoprotein cholesterol as well as desirable variations in high density lipoprotein cholesterol [ 83 ].

The way forward in the new decade. Innovative Drug Delivery Solutions.

Oral Drug Delivery Systems Comprising Altered Geometric Configurations for Controlled Drug Delivery

By manipulating the grade, quantity and exposed surface area of any hydrophilic polymer or mixture of polymers that erode constantly over time, the core-in-cup compressed tablet is able to deliver a constant amount of drug over time [ 99 ]. Multilayered hydrophilic matrices as constant release devices.

The triple layer provides an immediate release dose fraction, and a middle layer to regulate drug release from an extended release layer to prolong drug release and effect. The general mechanisms of action of triple-layered tablets include erosion of matrix layers, creation of a drug concentration gradient, limiting surface area of release of the swellable matrix by the barrier layers, erosion and swelling of the barrier layers to achieve a constant area for uniform drug release, as well as varying of the layers dissolution to achieve pulsatile or alternating release profiles [ 4064 ].